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Nutrient Depletion Caused by Drugs

Through our "Health Forensics" program we offer
nutrient depletion and interaction profiles for your drugs.

Top 10 Nutrient Depleting Drugs     Drugs     Nutrient Deficiencies

Antiarrhythmic agents: Digoxin depletes calcium, magnesium, phosphorus, and B1. Phenytoin, which is used for ventricular arrhythmia, as well as grand mal, simple partial and complex partial seizures, depletes the body of biotin, calcium, folic acid, thiamin, B12, vitamin D, and vitamin K.

Antihypertensives: Beta blockers (used for hypertension, angina, and arrhythmia) deplete coenzyme Q10. ACE inhibitors (benazepril, captopril, enalapril, fosinopril, lisinopril), collectively deplete the body of zinc. Hydrochlorothiazide and triamterene deplete the body of B6, folic acid, and calcium.

Antilipemic agents: Cholestyramine resin and colestipol deplete the body of beta-carotene, folic acid, vitamin A, B12, vitamin D, folic acid, vitamin E, vitamin K, calcium, iron, magnesium, phosphorus, and zinc. Statin drugs (atorvastatin, cerivastatin, fluvastatin, lovastatin, simvastatin) deplete the body of coenzyme Q10.

Antidiabetic agents: metformin (glucophage), acetohexamide (dymelor), glyburide (diabeta, glynase, prestab, micronase), tolazaminde (tolinase), tolbutamide (orinase), as a group deplete coenzyme Q10, with desipramine also depleting the body of B12. Since diabetes is a cardiovascular disease risk factor, the depletion of these nutrients places the individual at increased risk, because of the fact that coenzyme Q10 and B12 contribute to proper cardiovascular health.

Antibiotics: Besides destroying beneficial gut bacteria that aid digestion, protect against infection, and synthesize certain nutrients, tetracyclines (achromycin, sumycin, tetracap, panmycin), penicillins, cephalosporins, fluoroquinolones, and sulfonamides, deplete the body of B1, B2, B3, B6, B12, biotin, inositol, vitamin K, iron, and magnesium.

Antidepressants: Amoxapine (asendin), desipramine (norpramin), nortriptyline (aventyl hydrochloride), protriptyline (vivactil), amitriptyline (elavil), clomipramine (anafranil), doxepin (adapin), and imipramine (tofranil) deplete the body of coenzyme Q10 and B2.

Anti-inflammatory agents: The nonsteroidal anti-inflammatory drugs diclofenac, diflunisal, etodolac, fenoprofen, ibuprofen, ketoprofen, mefenamic acid, nabumetone, naproxen, and piroxicam all deplete the body of folic acid.

Estrogens (conjugated and esterified): Premarin, estratab, and menest, deplete the body of B6, magnesium, and zinc.

Robert L. Pastore, Ph.D., CNC, CN asks "What can be done?" - First, make sure the prescribed medication is absolutely necessary by seeking advice from a nutritionally oriented physician. If no alternatives are available, discuss the need for replacing the depleted nutrients with your primary care physician, in addition to working with a nutritionist to help you design a healthy diet. By obtaining information from health professionals, and working closely with your doctor, you can avoid being a victim of drugs that steal.


Best Pills Worst Pills II, Sidney M. Wolfe, MD, Rose-Ellen Hope, R.Ph, Public Citizen’s Health Research Group, Washington DC, 1993.

Drug-Induced Nutrient Depletion Handbook, Ross Pelton, RPh, Ph.D., CCN; James B. LaValle, RPh, DHM, NMD, CCN; Ernest B. Hawkins, RPh, MS; Daniel L. Drinsky, RPh, MS, Lexicomp Clinical Reference Library, 1999.

Heart Drugs, Martin Goldman, MD, Henry Holt Publishing, Inc., New York, 1992.

Singh RB; Niaz MA; Rastogi SS; Shukla PK; Thakur AS, “Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease.” J Hum Hypertens 1999 Mar;13(3):203-8.

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