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Arthritis
Helps -
The dangers of Vioxx, manufactured by Merck, were discovered in 2000.
The study known as VIGOR (Vioxx Gastrointestinal
Outcomes Research) showed an increased risk of serious cardiovascular events,
including heart attacks and strokes in patients taking Vioxx compared to
patients taking naproxen. This early
warning was ignored for almost 4 years by prominent scientists within the FDA
and Merck.
A
single attempt was made to warn the public about Vioxx.
This attempt failed. Dr. David J. Graham, associate director
for science in the
FDA
Drug
Center
's Office of Drug Safety, told Senate investigators that upon mentioning of the
risks, he was “ostracized”, “subjected to veiled threats” and
intimidated by co-workers at the pharmaceutically controlled FDA.
The
success of Vioxx was the result of ghost writing among medical journals, drug
company worship by both medical doctors and shareholders and million dollar
marketing campaigns ($100 million per year) paid for by the drug manufacturer.
Resultantly, the popularity of Vioxx and other NSAIDS gained surging
momentum on the prescription drug market. The
cold hard facts of science cannot be ignored forever.
The Wall Street Journal reported that Merck & Co.’s Vioxx
eventually led to more than 27,000 heart attacks and sudden cardiac deaths.
Still, Merck’s window of opportunity procured them $2.55 billion
dollars annually.
Vioxx
is not the only non steroidal anti-inflammatory drug (NSAID) that poses huge
risk to the general public. It is
estimated that 107,000 people are hospitalized every year for NSAID related
gastrointestinal complications. Adding
to this, at least 16,500 NSAID-related deaths occur each year among arthritis
patients. This figure, as reported by Dr. Gurkirpal Singh, is comparable to the
number of deaths from the acquired immunodeficiency syndrome [AIDS] and shows
that NSAIDS contribute to as many deaths as multiple myeloma, asthma, and
cervical cancer combined.
These
facts are shocking to a drug chemist like myself.
Isn’t the FDA supposed to protect the public from dangerous drugs?
Shouldn’t the American public be made aware of safe and effective
natural alternative’s? Apparently
not, financial gains appear to be more important.
Because natural alternatives do not carry patent protection, drug
manufacturers and the FDA will do little to promote them.
Combination therapy serve’s as a poignant example.
Using
three naturally occurring substances, anyone can safely and effectively prevent
and overcome osteoarthritis. Studies
show that osteoarthritis is the result of our body lacking the ability to
manufacture a molecule known as glucosamine
(perhaps
due to age, poor diet or genetics). This
inability to manufacture glucosamine leads to a lack of collagen.
Collagen
is the protein portion of the fibrous substance that holds joints together. It
is also the main component of the shock-absorbing cushion called articular
cartilage, the white, smooth
surface that covers the ends of body joints.
These cushions can be found in the wrist, fingers, toes, ankles, knees,
hips and between the discs of the spine. Without
articular cartilage, our joints experience pain and despite how healthy we may
be, this pain greatly inhibits physical activity. Lack of physical activity
inevitably leads to a decline in health.
The
obvious first step towards treating this pain and to prevent the subsequent
decline in health is to provide the body with an orally active form (one that
can make it past the stomach and into the blood stream) of glucosamine. After decades of
research, scientists have found this to be glucosamine sulfate rather than
glucosamine HCL.
Glucosamine
sulfate is derived from chitin, which is a processed form of shrimp, lobster,
and crab shells. Glucosamine sulfate is a derivative of the naturally occurring
aminomonosaccharide glucosamine
, a major
constituent of cartilage and synovial fluid. When supplemented properly
(1500-2500 mg daily for 6-8 weeks) glucosamine sulfate rebuilds lost cartilage
and soothes joints. Users can say
goodbye to pain. In an
unprecedented, 3-year, randomized, placebo-controlled, double blind study
involving 200 patients, supplementation with glucosamine sulfate retarded the
progression of osteoarthritis in the knee. Other
studies have confirmed these findings by showing that supplementation with
glucosamine sulfate slows down and reverses degeneration of cartilage within
joints.
These
studies are paramount in that no NSAID, including COX-2 inhibitors, have ever
been able to retard the progression of osteoarthritis. Trials, which compared
glucosamine
sulfate
to NSAIDS
such
as Ibuprofen
, showed that
long-term reductions in pain were greater in patients taking glucosamine
sulfate. Moreover,
long-term glucosamine administration does not elicit the potentially dangerous
side effects associated with the use of NSAIDS.
It
is believed that glucosamine
sulfate
supplementation is dangerous for diabetics. This is not true. Studies show that
due to the low glycemic index, there are no adverse effects when used at the
proper dose of 1500-3000 mg daily.
Enhancing
the effects of glucosamine
sulfate,
the nutrient MSM (methylsulfonylmethane or
dimethyl sulfone)
should be used in conjunction with it.
This is known as combination therapy. MSM is
an organic, sulfur-containing compound that occurs naturally in a variety of
fruits, vegetables, grains, and animals, including humans.
MSM (2-8 grams daily) works
double-time to heal joints by acting as an anti-inflammatory to the joints and
to inhibit pain
impulses along nerve fibers. Besides
helping arthritis (both osteoarthritis and rheumatoid) sufferers, MSM
can be of great benefit to those with bursitis, tendonitis and conditions such
as tennis elbow and repetitive strain injury. MSM is
a safe and non-toxic substance.
Highlighted
by the peer reviewed medical journal Clinical Drug Investigations,
combination therapy works better and faster at reducing pain and swelling and in
improving the functional ability of joints when compared to using glucosamine
sulfate and MSM individually. This
is an important note.
Offering
further benefits from combination therapy, ginger
has
also been shown to have unprecedented success at circumventing joint pain.
Zingiber officinale
(ginger
root) has been shown to be a potent inhibitor of both prostaglandins
(PGE2)
and leukotrienes (LTB4).
These biochemical’s are
ubiquitous substances that initiate and control cell and tissue responses
involved in a myriad of physiological processes. These processes include
platelet aggregation
, rennin release
and
inflammation. Their
overproduction has been implicated in the pathophysiology of cardiovascular
diseases, cancer
and
inflammatory diseases such as osteoarthritis. To circumvent the overproduction
of prostaglandins (PGE2) and leukotrienes (LTB4) one could use Ginger.
One study conducted by the Department of Environmental Medicine in
Denmark
showed that of 56 patients (2 with rheumatoid arthritis, 18 with osteoarthritis,
and
10 with muscular discomfort) taking Zingiber officinale, 75% experienced
relief in pain and swelling.
Combination
therapy with glucosamine
sulfate,
MSM
, and Ginger for 4
to 6 months is
America
’s answer to the growing number of people who suffer from osteoarthritis.
In contrast to NSAIDS
, such combination
therapy is inexpensive and elicits no negative side effects. These
substances, like water, are non-toxic. Hence,
ALL American’s have a remedy to not only arthritis but also the deadly
conflicts of interest among the FDA…Thanks to Mother Nature.
About
the Author
- Shane holds a Master’s degree in
organic chemistry and has first-hand industry experience with drug research,
design and synthesis. He understands
that Americans want and deserve education rather than prescriptions.
His shocking ebook surrounding cholesterol lowering drugs can be
downloaded for FREE as a pdf file at
www.health-fx.net/eBook.pdf
- Combination Therapy” at
www.health-fx.net.
If problems with download send email to services@healthmyths.net
References:
Pavelka,
Karel. et al. “Glucosamine Sulfate Use and Delay of Progression of Knee
Osteoarthritis.” Archives of Internal Medicine. Vol 162,
Oct 14, 2002
.
Alternative Medicine Review. Volume 4, Number 3. 1999.
Müller-Fasbender H, et al. “Glucosamine sulfate compared to ibuprofen in
osteoarthritis.” Osteo Cartilage. 1994; 2: 61-69.
Scroggie DA, et al. “The effect of glucosamine
-chondroitin supplementation on glycosylated hemoglobin levels in patients with
type 2 diabetes mellitus.” Archives of Internal Medicine. 2003;
163:1587-1590.
Singh Gurkirpal, MD, "Recent Considerations in Nonsteroidal
Anti-Inflammatory Drug Gastropathy.” The American Journal of Medicine.
July 27, 1998
, p. 31S.
Srivastava, KC. et al. “Ginger (Zingiber officianale) in rheumatism and
musculoskeletal disorders.” Medical Hypotheses. 1992 Dec;39(4):342-8.
Kiuchi, F. et al. “Inhibition of prostaglandin and leukotriene biosynthesis by
gingerols and diarylheptanoids.” Chemical and Pharmaceutical Bulletin (
Tokyo
). 1992 Feb;40(2):387-91. Srivastava,
KC. et al. “Ginger (Zingiber officianale) in rheumatism and musculoskeletal
disorders.” Medical Hypotheses. 1992 Dec;39(4):342-8.
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